Type 2 Diabetes – Maria Conley, M.D.

A practicing internal medicine physician talks about the new “G receptor” agonist weight loss medications– semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro) and the latest drug in the pipeline–retatrutide. We’ll see how retatrutide, a so-called “triple G agonist” may be the most effective weight loss medication of all. By adding the combined hormonal effects of GLP-1, GIP and glucagon, retatrutide led to a remarkable 24% weight loss in 1 year in a recent study. As an added benefit, the drug uses the glucagon effect to break down fat in your liver. **This is my independent analysis of the data. I am not receiving any compensation from drug manufacturers.**

A board certified internal medicine physician explains how two of the most effective weight loss strategies today —the medication semaglutide (Ozempic) and weight loss surgery—work by increasing the level of GLP-1 in your body. GLP-1 travels in your gut-brain axis via your bloodstream or by activating your vagus nerve. It works as a hormone and as a neuromodulator to change the way you think about food.

A board certified internal medicine physician discusses how the same insulin molecule is able to clear 2-3 times more glucose from your blood when it binds to receptors on muscle cells instead of fat cells. Also, fat stored in the visceral (abdominal) compartment is more likely to contribute to insulin resistance than fat stored in the subcutaneous compartment due to differences in blood flow. The relative amount of muscle and fat (visceral and subcutaneous) in your body can determine how effective your insulin is.

A board-certified internal medicine physician reviews how you can reverse type 2 diabetes with a low carbohydrate diet, especially if you start within a few years of your diagnosis.

A board-certified internal medicine physician discusses how type 2 diabetes is really a dietary disease and how the initial treatment should be a low carbohydrate diet. We also discuss how fatty liver and fatty pancreas contribute to the disease process. We review the difference between “healthy” fat and “unhealthy” fat based on where it is stored in the body.